New Views on Antidiarrheal Effect of Wood Creosote: Is Wood Creosote Really a Gastrointestinal Antiseptic?

New views on antidiarrheal effect of wood creosote: is wood creosote really a gastrointestinal antiseptic?

Wood creosote, the principal ingredient in Seirogan, has a long history as a known gastrointestinal microbicidal agent. When administered orally, the intraluminal concentration of wood creosote is not sufficiently high to achieve this microbicidal effect. Through further animal tests, we have shown that antimotility and antisecretory actions are the principal antidiarrheal effects of wood creos...

Demonstration of antidiarrheal and antimotility effects of wood creosote.

Wood creosote administered to rats prevented castor-oil-induced diarrhea with an ED50 of 53 mg/kg p.o. This antidiarrheal effect was apparently produced by acceleration of net fluid absorption from the intestine, as shown by a 52% decrease (p < 0.001) of residual fluid volume in an intestinal loop, and partly by suppression of intestinal motility. Wood creosote also inhibited spontaneous longit...

Non-Arsenical Wood Protection: Alternatives for CCA, Creosote, and Pentachlorophenol

Creosote movement from treated wood immersed in fresh water

Creosote has a long history of successful use as a wood preservative, but polycyclic aromatic hydrocarbons in this preservative have raised environmental concerns, particularly when creosote-treated wood is used in aquatic environments. A number of models have been developed to predict the risk of creosote use in aquatic environments, but one limitation of these models is a lack of data on the ...

Comparison of the antidiarrheal effects of wood creosote and loperamide in the rat jejunum and colon in vitro.

Wood creosote, a mixture of guaiacol, creosol and related compounds, has long been used as an antidiarrheal agent. The goal of our study was to investigate the antisecretory effect of wood creosote and to compare it to the effect of loperamide, a synthetic opioid widely used in the treatment of diarrhea. Experiments were performed in rat jejunal and colonic mucosal sheets, mounted in modified U...